Jimmy Fallon and Jamie Lee Curtis Parody Nathan Fielder and Elizabeth Holmes on The Tonight Show

Jimmy Fallon turned himself into Nathan Fielder on Wednesday night's episode of "The Tonight Show," with guest Jamie Lee Curtis playing Elizabeth Holmes in a parody of A24's much-discussed documentary "You Can See Everything."

In the sketch, Fallon, imitating Fielder's style, asked Curtis to be honest about whether she really wanted to be on the show that night. Curtis, wearing a blonde wig and staring intently into the host's eyes, answered in a Holmes-like voice: "Of course I do. I love talking to you."

Fallon then pressed on whether she was only there to promote her new show, "Newlyweds." Curtis said she was engaging with him "as a human being." She added: "Why would I deceive you? There's no reason for me to do that. There's nothing for me to deceive you on."

Fallon wrapped up with "Good chat," but first asked one more question: "You're being real right now?" Curtis replied, "I'm always being real." After Fallon walked away, she dropped the act and shouted a profane remark about him.

As the cold open noted, Curtis was on the program to promote "Newlyweds," her new NBC sitcom, which premiered on Oct. 23. Starring Téa Leoni and Tim Daly, the series is described in its logline as "a later-in-life love story about a free-spirited woman and a buttoned-up professor who marry impetuously after a whirlwind courtship."

Curtis co-created the show with Gail Lerner and will appear in a recurring guest star role. Lerner was fired from the series earlier this month over "creative differences." In her statement when the news broke, Lerner called the experience of working on the show "the most joyous TV experience of my life."

The film being parodied, "You Can See Everything," opened in theaters on Oct. 16 and has been a hit with critics and audiences. It has grossed $45.1 million domestically so far.

Fielder and co-director Lance Oppenheim worked quietly on the movie for more than three years. The film offers an unhinged look at the Theranos founder a month before she began an 11-year prison sentence for defrauding investors.